Chemopreventive and Antilipidperoxidative Efficacy of Piper longum (Linn.) on 7,12-dimethylbenz (a) anthracene (DMBA) Induced Hamster Buccal Pouch Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
INTRODUCTION Oral carcinoma accounts for 40-50 percent of all cancers in India. Tobacco chewing, smoking and alcohol consumption are the major risk factors associated with the high incidence of oral cancer in India. Our aim was to investigate the chemopreventive potential of curcumin and piperine during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. METHODS...
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The present study evaluated the chemopreventive potential of (6)-paradol, a pungent phenolic constituent of ginger, on 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The mechanistic pathway for the chemopreventive potential of (6)-paradol was evaluated by measuring the status of tumor incidence, volume and burden as well as by analyzing the status of phase II...
متن کاملAnticarcinogenic and antilipidperoxidative effects of Tephrosia purpurea (Linn.) Pers. in 7, 12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinoma
Objectives: To investigate the chemopreventive potential and antilipidperoxidative efDepartment of Biochemistry, fects of ethanolic root extract of Tephrosia purpurea (Linn.) Pers. (TpEt) on 7,12Faculty of Science, dimethylbenz(a)anthracene (DMBA)induced hamster buccal pouch carcinoma. Annamalai University Materials and Methods: Oral squamous cell carcinoma was developed in the buccal Annamalai...
متن کاملInduction of Apoptosis by Piper Betel Leaf Extract on 7, 12 Dimethylbenz [a] Anthracene Induced Hamster Buccal Pouch Carcinogenesis
The induction of apoptosis by Piper betel leaf extracts during 7, 12 dimethylbenz [a] anthracene (DMBA) induced hamster buccal pouch (HBP) carcinoma was studied in male Syrian hamsters using DNA fragmentation and the apoptosis-associated proteins, tissue transglutaminase (tTG) and Bcl-2. Hamsters were divided into four groups of six animals each. Animals in group 1 were painted with a 0.5% solu...
متن کاملChemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch squamous cell carcinogenesis.
OBJECTIVE Toona sinensis leaf extract (TSL) has been shown to have anti-tumor effects on cancer cell lines. This study aimed to investigate the chemopreventive potential and the underlying mechanism of TSL during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. METHODS One hundred hamsters were divided into control (n=30), carcinogenic (n=20), preventiv...
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ژورنال
عنوان ژورنال: Journal of Applied Sciences
سال: 2007
ISSN: 1812-5654
DOI: 10.3923/jas.2007.1036.1042